GLP-1 care, tailored to you

Fittlly focuses on modern, clinically validated GLP-1–based therapies. Today, our clinicians may prescribe two main active ingredients, when medically appropriate:
• Semaglutide (GLP-1)
• Tirzepatide (GLP-1/GIP)

Most patients receive these medicines as a once-weekly subcutaneous injection, using a very small insulin-style needle after being shown how to inject safely.

For patients who are not comfortable with injections or who may be better suited to another format, Fittlly may also offer an oral (tablet) form of semaglutide, when clinically appropriate and available.

The exact medication and format you’re offered will depend on your medical history, goals, preferences, and clinician judgment after your online evaluation.

In many cases, yes—if it’s clinically appropriate and allowed by pharmacy and state regulations, your clinician can authorize more than one vial at a time.

Some patients prefer to receive a month-to-month supply, while others may be eligible for a multi-month supply (for example, up to 3 months) so they don’t have to reorder as often. The amount you can receive at once depends on:
• your prescription and dose
• safety and monitoring needs
• pharmacy and shipping regulations in your state

During your Fittlly evaluation, your clinician and care team will let you know what options are available for you, and we’ll show your pricing and refill cadence clearly before you confirm your order.

GLP-1 (glucagon-like peptide-1) is a natural hormone released by your gut after you eat. It helps your body:
• release more insulin when blood sugar is high
• reduce glucagon (the hormone that tells your liver to release sugar)
• slow how quickly food leaves your stomach
• increase feelings of fullness and reduce appetite

GLP-1 medications (often called GLP-1 receptor agonists) are prescription drugs that mimic this hormone. By acting on the same receptors as your natural GLP-1, they can help:
• improve blood sugar control
• reduce hunger and cravings
• support lower calorie intake
• promote medically supervised weight loss when combined with lifestyle changes

In addition to GLP-1–only medicines (like semaglutide), there are also dual GLP-1/GIP treatments (like tirzepatide). GIP (glucose-dependent insulinotropic polypeptide) is another gut hormone that supports insulin release and satiety. Combining GLP-1 and GIP activity can further enhance metabolic effects in some patients, under clinical supervision.

Compounded GLP-1 (and GLP-1/GIP) medications are custom-made prescriptions prepared by a licensed compounding pharmacy for a specific patient, following a prescription from a licensed clinician. Drug compounding means mixing, adjusting, or reformulating ingredients to create a medication that isn’t available in a suitable form as a standard, FDA-approved product—for example:
• a different strength than what exists commercially
• a different formulation (e.g. without a certain dye, preservative, or excipient)
• a different route or form better suited to the patient’s needs

Because they are tailor-made, compounded GLP-1 and GLP-1/GIP products are not FDA-approved. That means the specific compounded preparation (the finished drug product) is not reviewed by the FDA for safety, effectiveness, or manufacturing quality, even when it uses FDA-registered ingredients and is prepared in state-licensed or FDA-inspected facilities. They may only be dispensed with a valid prescription from a licensed healthcare provider, when the clinician determines that a compounded option offers a meaningful difference compared with an FDA-approved drug.

At Fittlly, when a compounded GLP-1 or GLP-1/GIP therapy is prescribed, we work only with carefully vetted, state-licensed or FDA-inspected compounding pharmacies that follow USP standards and applicable federal and state regulations. We review their licenses, accreditations, sourcing of active ingredients, and quality processes so your medication is prepared in line with current safety and compliance expectations—while always keeping you informed that compounded products themselves are not FDA-approved.

Most people can use standard, FDA-approved GLP-1 medicines. However, in some situations a clinician may decide that a compounded GLP-1 or GLP-1/GIP medication is more appropriate because a commercially available product does not fully meet a patient’s needs. Examples can include:

Allergies or sensitivities to certain ingredients
Some patients cannot tolerate dyes, preservatives, or specific excipients found in FDA-approved products. A compounded version may be prepared without the problematic ingredient.

Need for a different strength or formulation
In some cases, a patient may require a dose strength or formulation that is not available as a ready-made, FDA-approved product. Compounding allows a pharmacist to prepare a tailored concentration under a clinician’s direction.

Swallowing or administration challenges
Certain patients (for example, older adults or people with swallowing difficulties) may not be able to use a particular form of medication. A compounded option may allow for a different route or format that is easier for them to use safely.

Clinical or logistical constraints
In hospital, clinic, or specialized care settings, practitioners may occasionally rely on compounded medications when an FDA-approved product is not medically appropriate or not reasonably available for a given patient.

In all of these cases, compounding is used to address a specific, documented clinical need, not simply as a convenience. Compounded GLP-1 and GLP-1/GIP medicines can only be provided with a prescription from a licensed healthcare professional, and they are generally reserved for situations where an FDA-approved option cannot adequately or safely meet the patient’s needs.

Compounded GLP-1 and GLP-1/GIP medications are not FDA-approved products. That means the specific compounded preparation you receive (the final vial, syringe, or pen) has not been reviewed or approved by the FDA for safety, effectiveness, or manufacturing quality in the same way as brand-name drugs like Wegovy® or Zepbound®.

However, when they are used, compounded medications are:
• prepared by licensed compounding pharmacies that must follow federal and state regulations
• typically made with active ingredients sourced from FDA-registered suppliers
• prescribed only when a licensed clinician believes a compounded option offers a meaningful difference versus an FDA-approved product (for example, a different strength or formulation).

No medication is completely without risk—compounded or FDA-approved. Safety depends on:
• your individual medical situation
• whether compounding is clinically appropriate for you
• the quality standards of the pharmacy preparing the medication
• being closely monitored by a licensed clinician.

At Fittlly, compounded GLP-1 therapies are only prescribed when medically justified, and only through vetted, state-licensed or FDA-inspected compounding pharmacies. Even so, it’s important to understand that compounded products themselves are not FDA-approved, and you should always discuss the potential risks and benefits with your clinician before starting treatment.

Fittlly partners with a small network of U.S.-based, state-licensed compounding pharmacies that prepare medications specifically to match each clinician’s prescription. These pharmacies are regulated by their state boards of pharmacy and must comply with applicable federal laws and guidance for compounding.

They are required to:
• follow relevant USP standards for sterile and non-sterile compounding
• use FDA-registered suppliers for active pharmaceutical ingredients
• compound only against valid, patient-specific prescriptions
• maintain strict procedures to avoid insanitary conditions and protect product quality

Many of these facilities may also be subject to inspection by the FDA or state authorities to ensure they are meeting safety and quality expectations.

We regularly review licenses, accreditations, and quality practices for our partner pharmacies so that, when a compounded GLP-1 or GLP-1/GIP is prescribed, you know it’s being prepared in a regulated U.S. facility that meets current professional standards—even though the compounded medication itself is not FDA-approved.

When a compounded GLP-1 or GLP-1/GIP medication is prescribed at Fittlly, our partner pharmacies prepare it using:
• a pure active ingredient (such as semaglutide or tirzepatide)
• a sterile diluent (for example, sterile water for injection)
• carefully selected inactive components to help maintain stability and potency over the intended use period

These inactive ingredients may include things like a small amount of alcohol or other standard excipients used in injectable medicines to support sterility, pH balance, and shelf-life.

What you will not find added are unnecessary flavors, dyes, or cosmetic fillers. Everything in the vial is there to:
• safely deliver the prescribed dose
• keep the solution stable and sterile
• meet pharmacy and compounding standards

If you have allergies, sensitivities, or concerns about specific ingredients (for example, alcohol, preservatives, or certain excipients), your clinician and pharmacy can review the exact formulation with you before treatment so you know precisely what you’re receiving.

No GLP-1 or GLP-1/GIP medication—compounded or brand-name—can promise a specific amount of weight loss. Results vary widely from person to person and depend on many factors, including your starting weight, medical history, dose, lifestyle, and consistency with treatment.

Clinical trials can give us a general idea of what’s possible under strict medical supervision:
• In a 68-week study of Wegovy® (semaglutide 2.4 mg) in adults without diabetes but with obesity or excess weight plus a weight-related condition, participants lost on average about 15% of their body weight when Wegovy® was combined with diet and exercise support, compared with about 2.4% with lifestyle changes alone.
• In a 72-week study of Zepbound® (tirzepatide 15 mg) in a similar population, the average weight loss was about 20% of body weight with medication plus lifestyle changes, compared with about 3.1% with lifestyle changes alone.

These are group averages from controlled trials, not guarantees. Some people lose more, some less, and some may not respond as expected. At Fittlly, GLP-1–based therapies are always used as part of a supervised medical program focused on safe, sustainable progress—not on chasing a specific number at any cost.

Results with GLP-1 and GLP-1/GIP medications are different for everyone. Some people notice changes in appetite or portion sizes within the first few weeks, while visible changes on the scale may take longer—often several weeks to a few months, especially while your dose is being slowly increased.

In clinical studies of medicines like Wegovy® and Zepbound®, many patients reached around 15–20% body weight reduction over about a year, which can work out to roughly 1–3 pounds per week on average for some people. But that is a group average from trials, not a promise of individual results.

Your own pace will depend on:
• your starting weight and medical history
• your dose and how your body tolerates it
• your nutrition, movement, sleep, and stress
• how consistently you follow your treatment plan

At Fittlly, GLP-1–based therapy is always combined with real lifestyle support and close clinical follow-up. The goal isn’t instant change, but steady, sustainable progress that protects your health over the long term.

Semaglutide is a prescription medication that belongs to a class of drugs called GLP-1 receptor agonists. It’s designed to act like a natural hormone your gut releases after you eat, called glucagon-like peptide-1 (GLP-1).

By activating GLP-1 receptors in the body, semaglutide can:
• help your pancreas release more insulin when blood sugar is high
• lower glucagon, the hormone that tells your liver to release stored sugar
• slow stomach emptying, so you feel full for longer after meals
• reduce appetite and cravings, which can lead to eating less over time

Semaglutide was first developed to help manage type 2 diabetes, and specific formulations are now also approved for chronic weight management in eligible adults when used together with nutrition, activity, and ongoing medical supervision.

Tirzepatide is a prescription medication that targets two key gut hormones involved in blood sugar and appetite control:
• GLP-1 (glucagon-like peptide-1)
• GIP (glucose-dependent insulinotropic polypeptide)

Because it activates both GLP-1 and GIP receptors, tirzepatide can:
• increase insulin release when your blood sugar is high
• lower glucagon, the hormone that signals your liver to release stored sugar
• slow stomach emptying, helping you feel fuller for longer after eating
• reduce appetite and cravings, which can naturally lead to eating less over time

Tirzepatide is used under medical supervision to improve metabolic health and support clinically guided weight reduction, always as part of a broader plan that includes nutrition, movement, and regular follow-up with a licensed clinician.

There isn’t a single “better” option for everyone. The right place to start depends on your medical history, your goals, your tolerance for side effects, and your clinician’s judgment.

Both medicines:
• are powerful, prescription-only treatments that work on incretin hormones
• can support clinically meaningful weight loss when combined with nutrition and lifestyle changes
• require medical supervision and regular follow-up

Semaglutide (GLP-1 only)
• acts on the GLP-1 receptor
• has very strong data for both type 2 diabetes and chronic weight management
• is sometimes chosen first when a more gradual, stepwise approach is preferred, or based on insurance, cost, or availability

Tirzepatide (GLP-1/GIP dual agonist)
• activates both GLP-1 and GIP receptors
• in several large clinical trials, has shown greater average weight loss than some GLP-1–only options, including semaglutide, in comparable populations
• however, more potency can also mean different side effect profiles, dose-titration needs, and considerations around cost and coverage

From a purely data point of view, tirzepatide often leads to larger average weight reductions in studies—but that does not mean it’s automatically the best first choice for every person.

At Fittlly, the decision to start with semaglutide or tirzepatide is made case by case by a licensed clinician after your online evaluation. They’ll consider:
• your weight and BMI
• your other conditions (diabetes, cardiovascular risk, GI history, etc.)
• your current medications
• cost, access, and your preferences

The goal isn’t just “maximum loss at any price,” but the safest, most sustainable option for you over the long term.

Both oral and injectable GLP-1 medications work through the same hormone pathway, but they’re not identical in how they’re absorbed or how strong their effect can be.

Injectable GLP-1s
• Deliver the medication directly into the body under the skin, rather than through the digestive system
• Have the most robust clinical data for both blood sugar control and weight reduction
• Often allow for higher effective doses, which in many studies has translated into greater average weight loss for many patients

Oral GLP-1 options
• Are taken as a tablet by mouth, which some people find more familiar or less intimidating than injections
• Travel through the digestive system, so absorption can vary more between individuals
• May be a good fit for patients who can’t or don’t want to use injections, when clinically appropriate

Effectiveness for any individual depends on factors like dose, adherence, metabolism, other medical conditions, and lifestyle changes. In general, injectable GLP-1s tend to deliver stronger and more consistent results in trials, but convenience and personal preference matter too.

At Fittlly, your clinician will review your history, goals, and preferences and help you decide whether an injectable or (where available) oral GLP-1 option makes the most sense for you.

We do not currently provide Zofran® (ondansetron) or other prescription anti-nausea medications through Fittlly.

Mild nausea can be a common side effect when starting a GLP-1 or GLP-1/GIP treatment, especially while your dose is being increased. For many people, it improves over time with simple measures such as:
• eating smaller, more frequent meals
• avoiding very heavy, greasy, or spicy foods
• drinking water in small sips throughout the day
• not lying flat immediately after eating

Some patients discuss over-the-counter options such as vitamin B6 (pyridoxine) or other remedies with their own healthcare provider. Because every medical situation is different, Fittlly does not recommend specific products, dosages, or schedules on the website.

If your nausea is persistent, severe, or worrying, or if you are interested in medicines like Zofran®, you should speak directly with your primary care physician or prescribing clinician. They can evaluate your symptoms, advise on safe treatment options (including whether a prescription anti-nausea medication is appropriate), and adjust your GLP-1 plan if needed.

If you’re already a Fittlly patient and you’re struggling with nausea, please reach out to your care team so we can help you safely troubleshoot and support you.

We don’t currently offer vitamin B12 injections or supplements as a standalone “energy” add-on through Fittlly. Our focus today is on clinically guided GLP-1 and GLP-1/GIP therapies for metabolic health and weight management.

That said, vitamin B12 can be important for energy, mood, and nerve function, especially in people who are deficient (for example, some vegetarians/vegans, older adults, or patients with certain gut conditions). If you suspect low B12 or feel unusually tired, the safest next step is to talk to your primary care provider about a blood test and personalized treatment if needed.

We are actively exploring additional supportive options for the future, and may expand our offerings over time. If and when B12 becomes part of a Fittlly program, it will be added under medical supervision and clearly explained in your plan.

1. About GLP-1 medications – FDA consumer information

2. About GLP-1/GIP medications – dual agonists overview (Cleveland Clinic)

3. Human Drug Compounding – U.S. Food and Drug Administration (FDA)

4. Compounding and the FDA: Questions and Answers

5. Section 503A of the Federal Food, Drug, and Cosmetic Act (FDCA)

6. Tirzepatide – MedlinePlus drug information